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Home > Products > Pharmaceutical And Medical > Anti-tumor And Anti-cancer Drugs > 99% (titration) +Pharma Grade Tolazoline Hydrochloride 59-97-2 Tolazoline HCl

99% (titration) +Pharma Grade Tolazoline Hydrochloride 59-97-2 Tolazoline HCl

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Basic Info

Model No.:  59-97-2

Product Description

Model NO.: 59-97-2 Customized: Customized Suitable for: Adult Purity: >99% Payment Terms: Western Union, Moneygram, Jp Morgan Chase Grade: Pharmaceutical Grade MW: 196.6766 Transport Package: Disguised Origin: China Powder: No Certification: GMP, ISO 9001, USP, BP State: Powder CAS: 59-97-2 Quality Standard: Cp/USP/Bp/Ep  Mf: C10h13cln2 Trademark: SENDI Specification: White Powder 99%(titration)+Pharma Grade Tolazoline Hydrochloride 59-97-2 Tolazoline Hcl with High Purity

Quick Detail:

Product Name: Tolazoline hydrochloride
Synonyms: 2-Benzyl-2-imidazoline hydrochloride; Tolazoline HCl; 2-BENZYL-2-IMIDAZOLINE CHLORHYDRATE; 2-benzyl-4,5-dihydro-1H-imidazole hydrochloride (1:1)
Molecular Formula: C10H13ClN2
Molecular Weight: 196.6766
InChI: InChI=1/C10H12N2.ClH/c1-2-4-9(5-3-1)8-10-11-6-7-12-10;/h1-5H,6-8H2,(H,11,12);1H
CAS Registry Number: 59-97-2
EINECS: 200-447-3
Molecular Structure: 59-97-2
Melting point: 172-176ºC
Boiling point: 338.2°C at 760 mmHg
Flash point: 158.3°C
Vapour Pressur: 0.000196mmHg at 25°C
Risk Codes: R22:Harmful if swallowed.;
Safety Description: S22:Do not inhale dust.;
Quality Standards: CP/USP/BP/EP 
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Tolazoline hydrochloride Introduction:

Tolazoline is a competitive α1- and α2-adrenergic receptor antagonist (pKis ~6.5) well-known for its peripheral vasodilator effects in animal models.1,2 It also is reported to produce histamine-like effects that are sensitive to histamine H2-receptor antagonism in whole animals and a variety of isolated tissues.3 Certain α2-adrenergic receptor antagonists, including tolazoline, are most commonly used in veterinary medicine as reversal agents for the sedative effects of α2-adrenergic receptor agonists such as xylazine

Tolazoline hydrochloride belongs to the synthetic group of alpha-adrenergic blocking agents known as imidazole derivatives. It is a mixed alpha-1 and alpha-2 adrenergicreceptor antagonist that competitively inhibits alpha-adrenoreceptors. Tolazoline isalso a direct peripheral vasodilator that decreases peripheral resistance and increases venous capacitance. 

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Tolazoline hydrochloride COA
 
Product name Tolazoline Hydrochloride MFG. Date 20170110
Package 1kg/bag Batch number FH-20170110
Testing Date 20170110 Exp Date 20190110
Standard USP32 Quantity 100kg
Cas No. 59-97-2 EINECS NO. 200-447-3
Molecular Formula C10H13ClN2 Molecular Weight 196.68
Function Main functions are as follows:
As short-acting receptor blocking drugs
Applications Main applications are as follows:
Medicine
Synonyms 2-Benzyl-2-imidazoline hydrochloride
Items Tested Specification Result
Characters White or off-white crystalline powder Confirms
Assay (HPLC) 99.0~101.0% Confirms
Density 1.09g/cm3 Confirms
Flash Point 158.3 Degree Confirms
Boiling Point 338.2Degree at 760mmHg Confirms
Melting point 172~176Degree Confirms
Conclusion Conforms USP32

Tolazoline hydrochloride Dosage

The tolazoline hydrochloride dose is 4.0 mg/kg body weight or 1.8 mg/lb. (4ml/100kg or 4ml/220 lb.) to reverse the sedative effects of xylazine hydrochloride in horses.
In studies with cervids, a dose of 2mg/kg of tolazoline to reverse xylazine in deer, resulted in a reduced time to standing.
Tolazoline hydrochloride should be administered slowly by intravenous injection at a rate of approximately 1 ml per second. Onset of arousal is usually apparent within 5 minutes of tolazoline hydrochloride administration, depending on depth and duration of xylazine-induced sedation.

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