Model NO.: CAS 58186-27-9 Customized: Non-Customized Suitable for: Adult Purity: >99% Characters: White Crystalline Powder Sample: Free Transportation: DHL, UPS, TNT, EMS, FedEx or Other Transport Package: 1kg/Bag, 25kg Origin: China Powder: Yes Certification: GMP, ISO 9001, Ep5 State: Solid Model No: 58186-27-9 Standard: USP/Bp MOQ: 10g Trademark: Sendi Specification: 1kg/bag, 25KG HS Code: 3001200010 Idebenone
Assay:99% min pure
Appearance: orange-yellow crystalline powder
Catalogue:Pharmaceutical materials;Health supplements;APIs;Brain health drug;Nootropic
Other Nootropics we offer:noopept;hydroxypiracetam;piracetam;Ferulic Acid;COLURACETAM
What is Idebenone
Idebenone (pronounced eye-deb-eh-known, trade names Catena, Raxone, Sovrima, among others) is a drug that was initially developed by Takeda Pharmaceutical Company for the treatment of Alzheimer's disease and other cognitive defects.This has been met with limited success. The Swiss company Santhera Pharmaceuticals has started to investigate it for the treatment of neuromuscular diseases
Idebenone are used for:
Nootropic effects and Alzheimer's disease
Idebenone improved learning and memory in experiments with mice.In humans, evaluation of Surrogate endpoints like electroretinography, auditory evoked potentials and visual analogue scales also suggested positive nootropic effects, but larger studies with hard endpoints are missing.
Friedreich's ataxia (Sovrima)
Preliminary testing has been done in humans and found idebenone to be a safe treatment for Friedreich's ataxia (FA), exhibiting a positive effect on cardiac hypertrophy and neurological function.The latter was only significantly improved in young patients. In a different experiment, a one-year test on eight patients, idebenone reduced the rate of deterioration of cardiac function, but without halting the progression of ataxia.
Other neuromuscular diseases
Phase I and II clinical trials for the treatment of MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) and primary progressive multiple sclerosis are ongoing as of December 2013.
Pharmacokinetics of Idebenone
Idebenone is well absorbed from the gut but undergoes excessive first pass metabolism in the liver, so that less than 1% reach the circulation. This rate can be improved with special formulations (suspensions) of idebenone and by administering it together with fat food; but even taking these measures bioavailability still seems to be considerably less than 14% in humans. More than 99% of the circulating drug are bound to plasma proteins. Idebenone metabolites include glucuronides and sulfates, which are mainly (~80%) excreted via the urine.
Other Nootropics Drug Pharmaceutical Raw Material
|NO.1 ||Noopept ||CAS:157115-85-0 |
|NO.2 ||Piracetam ||CAS:7491-74-9 |
|NO.3 ||Idebenone ||CAS:58186-27-9 |
|NO.4 ||phenylpiracetam ||CAS:77472-70-9 |
|NO.5 ||Pramiracetam ||CAS:68497-62-1 |
|NO.6 ||Rivastigmine ||CAS:123441-03-2 |
|NO.7 ||Coluracetam ||CAS:135463-81-9 |
|NO.8 ||Entacapone ||CAS:130929-57-6 |
|NO.9 ||Oxiracetam ||CAS:62613-82-5 |
|NO.10 ||Aniracetam ||CAS:72432-10-1 |
|NO.11 ||Donepezil ||CAS:120014-06-4 |
|NO.12 ||brivaracetam ||CAS:357336-20-0 |
|NO.13 ||Etiracetam ||CAS:33996-58-6 |
|NO.14 ||Raubasine ||CAS:483-04-5 |
|NO.15 ||Rivastigmine tartrate ||CAS:129101-54-8 |
|NO.16 ||Sunifiram ||CAS:314728-85-3 |
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