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Home > Products > Pharmaceutical And Medical > Others Pharmaceutical And Medical > High Quality L-Thyroxine (Standard: USP, NF, BP, EP, CP) Levothyroxine 51-48-9

High Quality L-Thyroxine (Standard: USP, NF, BP, EP, CP) Levothyroxine 51-48-9

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Basic Info

Model No.:  51-48-9

Product Description

Model NO.: 51-48-9 Customized: Customized Suitable for: Adult Purity: >99% Payment Terms: Western Union, Moneygram, Jp Morgan Chase Grade Standard: Medicine Grade MW: 776.87 Transport Package: Disguised Origin: China Powder: No Certification: GMP, ISO 9001, USP, BP State: Powder CAS: 51-48-9 Grade: Pharmaceutical Grade Mf: C15h11I4no4 Trademark: SENDI Specification: white to light yellow crystal powder High Quality L-Thyroxine (Standard:USP,NF,BP,EP,CP ) 51-48-9

Levothyroxine

L-Thyroxine Alias: T4 ; tetraiodothyronine;L-Thyroxine
L-Thyroxine CAS NO: 51-48-9
L-Thyroxine Einecs No: 200-101-1
L-Thyroxine MF: C15H11I4NO4
L-Thyroxine MW: 776.87
L-Thyroxine Purity: 98.0%
Appearance: White crystal. This product soluble in alkali solution, insoluble in water
Function and Application: It can promote general tissue metabolism and improve nerve excitability and physical development. It used for the treatment of hypothyroidism, myxedema and cretinism.

L-Thyroxine Usage :
One of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroi d hormone, but has been used to treat hyperlipidemia.

L-Thyroxine Properties:
it is white odorless and tasteless needle-like crystal. L type is hite crystals. Decompose at 235 - 236 degree Celsius. Optical rotation is -4.4 degree (3% at 0.13 mol/L NaOH in 70% ethanol). L type has strong activity. It promotes cell metabolism, increases oxygen consumption, and stimulates tissue growth, maturation and differentiation.

L-Thyroxine COA 
Test Specifications Result
Appearance Almost white crystalline powder white crystalline powder
Identification
(1)iodine
(2)color
 
1)flame decomposes andlibetates iodine vapors
2)add solution,a pink colour peoduced
 
1)Pass
2)Pass
Solubility 1)Very Slightly Soluble in Water
2)Soluble in Solutions of Alkali hydeoxides and in hot solutions of Alkli Carbonates
3)Slightly Soluble in Alcohol
4)Insoluble in Acetone,Chloroform and in Ether
1)Pass
2)Pass
3)Pass
4)Pass
Specific optical rotation -5°~-6°
(Sol 3.0% mixture from NaOH 1N/Ethanol 1:2)
-5.8°
Loss on drying ≤11.0% 9.60%
Liothyronine ≤2.0% 0.8%
Iodide ≤0.08% 0.06%
Assay 97.0%~103.0% 98.6%
Conclusion Conforms to USP30
Standard: CP2010

Levothyroxine is typically used to treat hypothyroidism, and is the treatment of choice for patients with hypothyroidism, who often require lifelong thyroid hormone therapy. It may also be used to treat goitervia its ability to lower thyroid-stimulating hormone (TSH), a hormone that is considered goiter-inducing. Levothyroxine is also used as interventional therapy in patients with nodular thyroid disease or thyroid cancer to suppress thyroid-stimulating hormone (TSH) secretion.  

Levothyroxine (INN, USAN) or L-thyroxine is a synthetic thyroid hormonethat is chemically identical to thyroxine (T4), which is naturally secreted by the follicular cells of the thyroid gland. It is used to treatthyroid hormone deficiency, and occasionally to prevent the recurrence of thyroid cancer. Like its naturally secreted counterpart, levothyroxine is a chiral compound in the L-form. The related drug dextrothyroxine (D-thyroxine) was used in the past as a treatment for hypercholesterolemia(elevated cholesterol levels) but was withdrawn due to cardiac side effects.
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