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Home > Products > Pharmaceutical And Medical > Others Pharmaceutical And Medical > Lappaconitine Hydrobromide Powder Natural Products CAS 97792-45-5 Local Anesthesia

Lappaconitine Hydrobromide Powder Natural Products CAS 97792-45-5 Local Anesthesia

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Basic Info

Model No.:  CAS 97792-45-5

Product Description

Model NO.: CAS 97792-45-5 Customized: Non-Customized Suitable for: Adult Purity: >99% Characters: White Crystalline Powder Sample: Free Transportation: DHL, UPS, TNT, EMS, FedEx or Other Transport Package: 1kg/Bag, 25kg Origin: China Powder: Yes Certification: GMP, ISO 9001, Ep5 State: Solid Model No: 20830-75-5 Standard: USP/Bp MOQ: 10g Trademark: Sendi Specification: 1kg/bag, 25KG HS Code: 3001200010 Lappaconitine hydrobromide (LH)
Product name:Lappaconitine hydrobromide
Other name:LH
CAS No:97792-45-5
Molecular formula:C32H45BrN2O8
Molecular weight:665.61
EINECS:N/A
Appearance:White or off white crystalline powder
Catalogue:Pharmaceutical materials

What is Lappaconitine hydrobromide (LH)
(1)Lappaconitine hydrobromide (LH) was an alkaloidal hydrobromate extracted from the roots of Aconitum Sinomontanum Nakai (Ranunculaceae).
(2)LH was soluble in methanol and hexane, slightly soluble in water, very slightly soluble in ethanol, but practically insoluble in chloroform.

Lappaconitine hydrobromide (LH) are used for:
Due to the relatively strong analgesic effect, LH was a good non-addictive anodyne and an effective therapy for various pain symptoms in clinic, such as postoperative pain, gastrointestinal ulcer, gastritis, hepatitis, rheumatoid arthritis, sciatica, headache caused by cold and so on. The applications show that LH indeed provide an good analgesia effect on patients with advanced cancer and certain chronic patients. As a surgical analgesic and an adjuvant drug for radiotherapy and chemotherapy, LH was used in the treatment of cancer pain and simultaneously in improving general symptoms of tumor patients to enhance immune function. Analgesic effect of LH was seven times as strong as aminopyrine, equivalent with dolantin
Because the efficacy kept for a long time without teratogenic effect, mutagenesis or accumulative intoxication, LH was a good non-addictive analgesic.

Lappaconitine hydrobromide (LH) CERTIFICATE OF ANALYSIS
Items of analysis Specification Results
Description a white to off-white powder white powder
Marker Compound Lappaoonite Hydrobromide 98.8%
Odor & Taste Characteristic Conform
Plant Part Used Root Conform
Extract Solvent   Water & Ethanol Conform
Method of Extraction   Soak and carry Conform
Mesh Size 80 100%
Loss on Drying ≤1.0% 0.3%
Ash Content   ≤5.0% 0.6%
Solvent Residue ≤0.05% Negative
Total Heavy Metals ≤10ppm Conform
Arsenic (As) ≤2ppm Conform
Cadmium (Cd)   ≤1 ppm Conform
Lead (Pb) ≤5 ppm Conform
Mierobiology ≤0.5 ppm Conform
Sulphate Negative Conform
Phosphate Organics   Negative Conform
Organics Residues   Negative Conform
Pesticides Residues Negative Conform
Total Plate Count    ≤1000cfu/g Conform
Total Yeast & Mold   ≤100cfu/g Conform
E. Coli   Negative Conform
Salmonella   Negative Conform
Staphylococcus Negative Conform
 
How Lappaconitine hydrobromide (LH) Works
LH was an insoluble drug taken in low dose. As an analgesic, there was a requirement in clinic that its preparations ought to have the characteristics of fast absorption and rapid action in order to relieve pain quickly. However, lappaconitine hydrobromide tablets sold in market belong to conventional tablet formulation. The properties of excipient employed in preparation result in long disintegration time, low dissolution rate, fast action and low bioavailability, which cannot satisfy the clinical requirements [13-15]. Therefore, a new preparation was urgently needed to be developed to improve the bioavailability and to reduce the times of administration for convenient administration. According to the WHO three ladder acesodyne principle, non-invasive administration was the first choice in treating cancer pain and thus LH was made into transdermal preparation with the advantages of convenient administration and non-invasion. It avoided gastrointestinal damage of drug and hepatic first pass effect, and reduces the toxicity and side effects and the times of administration. In addition, it led to steady-state plasma concentration and long effect, was convenient for long-term administration and rarely had psychological dependence (addiction). Based on its physicochemical properties, pharmacological effects and the requirement of fast absorption and rapid action in clinic, LH was made into transfersomes, which had small the particle size, fast percutaneous absorption, short onset time and good analgesia effect, to improve bioavailability.

Other Pharmaceutical Raw Material
  Pharmaceutical Raw Material  
  NAME CAS
NO.1 Tacrolimus 104987-11-3
     
NO.3 Cabergoline 81409-90-7
NO.4 Methandriol Dipropionate 3593-85-9
NO.5 Misoprostol 59122-46-2
     
     
NO.8 T3 55-06-1
NO.9 T4 25416-65-3
NO.10 Trilostane 13647-35-3
NO.11 Mebolazine 3625-07-8
NO.12 Abiraterone 154229-19-3
     
NO.14 Chitosan 9012-76-4
NO.15 Arbutin 497-76-7
NO.16 Glutathione Glutathione
NO.17 Dexamethasone Sodium Phosphate 55203-24-2
NO.18 Atorvastatin Calcium 134523-03-8
NO.19 Paracetamol 103-90-2
NO.20 Pramipexole 191217-81-9
NO.21 Pregabalin 148553-50-8
NO.22 Triamcinolone Acetonide 76-25-5
NO.23 Elubiol / Dichlorophenylimidazoldioxolan 67914-69-6
NO.24 Ketoconazole 65277-42-1
NO.25 Raloxifene Hydrochloride 82640-04-8
NO.26 Idebenone 58186-27-9
NO.27 Theophylline 58-55-9
NO.28 Glabridin 59870-68-7
NO.29 Lorcaserin 616202-92-7
NO.30 L-Epinephrine Hydrochloride 55-31-2
NO.31 Melatonin 73-31-4
NO.32 Dextromethorphan Hydrobromide 6700-34-1
NO.33 Minoxidil / Loniten / Lonolox / Minona 38304-91-5
     
NO.35 Hyaluronic Acid 9004-61-9
NO.36 Hydroxypropyl-Beta-Cyclodextrin 94035-02-6
NO.37 Minoxidil sulphate 83701-22-8
NO.38 Hydroxyprogesterone 68-96-2
NO.39 Estradiol benzoate 50-50-0
NO.40 ethinylestradiol 57-63-6
     
NO.42 halodrol N/A
NO.43 methyldienedione. 5173-46-6
NO.44 lorcaserin hydrochloride 846589-98-8
     
NO.46 Dapoxetine hydrochloride 119356-77-3

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