Model NO.: CAS 78755-81-4 Customized: Non-Customized Suitable for: Adult Purity: >99% Flumazenil Purity: 99.8% Characters: White Crystalline Powder MOQ: 10g Packing: 100g/Foil Bag or as Your Requirement Transport Package: 1kg/Bag, 25kg Origin: China Powder: Yes Certification: GMP, ISO 9001, Ep5 State: Solid Model No: 78755-81-4 Standard: USP3 Guarantees The Nature Time: 36 Months Transportation: DHL, UPS, TNT, EMS, FedEx or Other Trademark: Sendi Specification: 1kg/bag, 25KG HS Code: 3001200010 Product name:Flumazenil
Appearance: White crystalline powder
Catalogue:Pharmaceutical materials drug
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What is Flumazenil
Reversing drowsiness, sedation, and other effects caused by benzodiazepine
Flumazenil is a benzodiazepine antagonist. It works by blocking receptors in the brain and central nervous system that benzodiazepine need to reach to be active, which helps reduce drowsiness and sedation.
Flumazenil benefits and effects:
(1)Flumazenil is of benefit in patients who become excessively drowsy after benzodiazepine are used for either diagnostic or therapeutic procedures.
(2)It has been used as an antidote in the treatment of benzodiazepine overdoses. There are many complications that must be taken into consideration when used in the acute care setting.These include lowered seizure threshold, agitation, and anxiousness. Flumazenil's short half-life requires multiple doses and careful patient monitoring to prevent recurrence of overdose symptoms.
(4)Flumazenil has been effectively used to treat overdoses of non-benzodiazepine hypnotics, such as zolpidem, zaleplon and zopiclone.
Flumazenil CERTIFICATE OF ANALYSIS
|Items of analysis ||Specification ||Results |
|Appearance ||White crystalline powder ||White Crystalline Powder |
|Identification ||The sample'S IR spectrum is according with spectrum of Flumazenil,The retention time of the major peak Flumazenil in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation ||Conforms |
|Melting point ||198ºC to 202ºC ||200.6ºC to 200.9ºC |
|Appearance of solution ||The solution is clear and is not Intenser than reference solution BY7 ||Conforms |
|Impurity C || NMT 0.2% ||0.02% |
|Impurity A ||NMT 0.10% ||Not detected |
|Impurity B ||NMT 0.2% ||0.03% |
|Impurity D ||NMT 0.10% ||0.03% |
|Impurity E ||NMT 0.10% ||Not detected |
|Impurity F ||NMT 0.10% ||Not detected |
|Individual unknown impurituy ||NMT 0.10% ||0.02% |
|Total impurities ||NMT 0.5% ||0.1% |
|Loss on drying ||NMT 0.5% ||0.2% |
|Sulphated ash ||NMT 0.1% ||0.05% |
|Heavy metals ||≤0.5 ppm ||5ppm |
|Microbial limits( for Injection) ||Bacteria not more than 50CFU/g ||<10 CFU/g |
|Microbial limits ||Mildew and microzyme not more than 50CFU/g ||<10 CFU/g |
|Microbial limits ||Escherichia coli absence ||Absence |
|Ethanol ||NMT2000ppm ||Not detected |
|Chloroform || NMT30ppm ||Not detected |
|Acetic acid || NMT4000ppm ||Not detected |
|Dichloromethane ||NMT600ppm ||<0.002% |
|Ethyl ethanoate ||NMT5000ppm ||<0.003% |
|DMF ||NMT750ppm ||Not detected |
|Assay (On dried substance) ||98.0-102.0% ||99.80% |
|Bacterial endotoxins ||not more than 25.0 USP Endotoxin Units per mg of flumazenil. ||not more than 8.0 USP Endotoxin Units per mg of flumazenil. |
|Guarantees the nature time ||36 months ||36 months |
Other Pharmaceutical Raw Material
|NO.1 ||Noopept ||CAS:157115-85-0 |
|NO.2 ||Piracetam ||CAS:7491-74-9 |
|NO.3 ||Idebenone ||CAS:58186-27-9 |
|NO.4 ||phenylpiracetam ||CAS:77472-70-9 |
|NO.5 ||Pramiracetam ||CAS:68497-62-1 |
|NO.6 ||Rivastigmine ||CAS:123441-03-2 |
|NO.7 ||Coluracetam ||CAS:135463-81-9 |
|NO.8 ||Entacapone ||CAS:130929-57-6 |
|NO.9 ||Oxiracetam ||CAS:62613-82-5 |
|NO.10 ||Aniracetam ||CAS:72432-10-1 |
|NO.11 ||Donepezil ||CAS:120014-06-4 |
|NO.12 ||brivaracetam ||CAS:357336-20-0 |
|NO.13 ||Etiracetam ||CAS:33996-58-6 |
|NO.14 ||Raubasine ||CAS:483-04-5 |
|NO.15 ||Rivastigmine tartrate ||CAS:129101-54-8 |
|NO.16 ||Sunifiram ||CAS:314728-85-3 |
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