Model NO.: CAS 755037-03-7 Customized: Non-Customized Suitable for: Adult Purity: >99% Product Purity: 99.82% Standard: USP/Bp MOQ: 10g Trademark: Sendi Specification: 1kg/bag, 25KG HS Code: 3001200010 Powder: Yes Certification: GMP, ISO 9001, Ep5 State: Solid Model No: 755037-03-7 Characters: White Crystalline Powder Sample: Free Transportation: DHL, UPS, TNT, EMS, FedEx or Other Transport Package: 1kg/Bag, 25kg Origin: China Regorafenib(Stivarga)
Other name:Stivarga;BAY 73-4506
Appearance: White crystalline powder
Catalogue:Pharmaceutical materials drug
Moisture [water] content:0.06%
What is Regorafenib(Stivarga)
Regorafenib (BAY 73-4506, commercial name Stivarga) is an oral multi-kinase inhibitor developed by Bayer which targets angiogenic, stromal and oncogenic receptor tyrosine kinase (RTK). Regorafenib shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Since 2009 it was studied as a potential treatment option in multiple tumor types. By 2015 it had 2 US approvals for advanced cancers.
How regorafenib works
(1)Regorafenib works by blocking particular proteins on cancer cells that encourage the cancer to grow. These proteins are called protein kinases. Regorafenib is called a protein tyrosine kinase inhibitor (TKI) or cancer growth blocker.
(2)Regorafenib stops a number of different proteins being made and is called a multi kinase inhibitor. It works by stopping signals that tell cancer cells to grow. It also stops the cancer cells growing blood vessels that they need. Blocking blood vessel growth is called anti angiogenesis treatment.
(3)Regorafenib may shrink the cancer or stop it growing for a time.
How you have regorafenib
(1)Regorafenib comes as tablets. The usual dose is 4 tablets. You take them once a day. Your doctor may change the dose.
(2)You take regorafenib for 3 weeks and then you stop for 1 week. This is one cycle of treatment. Then the cycle starts again. You usually carry on taking regorafenib for as long as it works.
(3)You should take regorafenib at the same time each day after a low fat meal.
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